A new method of determination of the I-Vcharacteristics of negative differential conductance devices

A method for mapping the complete I-V characteristic of a negative differential conductance (NDC) device has been investigated. This method employs the measurable positive differential conductance (PDC) portions of the DC I-V curve together with the measured conductances at a fixed DC bias voltage in the PDC region with different RF signal levels using a standard semiconductor analyzer. The NDC regime of the I-V curve is numerically constructed from the measured conductances at a fixed DC bias voltage in the PDC region with different signal levels using a large-signal nonlinear-circuit analysis     

Adenocarcinoma combined with malignant peripheral nerve sheath tumor of the gallbladder

Adenocarcinoma of the gallbladder combined with a malignant peripheral nerve sheath tumor (MPNST) in the gallbladder in an 81-year-old woman is reported. The resected gallbladder showed two distinct tumor components, the epithelioid type of MPNST and adenocarcinoma with areas of mucin production. Although the immediate postoperative course was uneventful, a pathologic fracture of her right upper femur developed 4 months after the cholecystectomy. The pathology was determined to be a feature of metastatic MPNST rather than of adenocarcinoma. A whole body bone scan revealed multiple metastases, including the left parietal skull, left ninth rib, seventh thoracic vertebra, and right upper third of the femur. Despite cholecystectomy and postoperative irradiation therapy, she died 6 months after diagnosis of the tumor. Without an autopsy the primary site of the MPNST was unknown. We found that the prognosis was very poor in patients with distal metastatic MPNST, especially in older patients.     

Immunizing patients with metastatic melanoma using recombinant adenoviruses encoding MART-1 or gp100 melanoma antigens

BACKGROUND: The characterization of the genes encoding melanoma-associated antigens MART-1 or gp100, recognized by T cells, has opened new possibilities for the development of immunization strategies for patients with metastatic melanoma. With the use of recombinant adenoviruses expressing either MART-1 or gp100 to immunize patients with metastatic melanoma, we evaluated the safety, immunologic, and potential therapeutic aspects of these immunizations. METHODS: In phase I studies, 54 patients received escalating doses (between 10(7) and 10(11) plaque-forming units) of recombinant adenovirus encoding either MART-1 or gp100 melanoma antigen administered either alone or followed by the administration of interleukin 2 (IL-2). The immunologic impact of these immunizations on the development of cellular and antibody reactivity was assayed. RESULTS: Recombinant adenoviruses expressing MART-1 or gp100 were safely administered. One of 16 patients with metastatic melanoma receiving the recombinant adenovirus MART-1 alone experienced a complete response. Other patients achieved objective responses, but they had received IL-2 along with an adenovirus, and their responses could be attributed to the cytokine. Immunologic assays showed no consistent immunization to the MART-1 or gp100 transgenes expressed by the recombinant adenoviruses. High levels of neutralizing antibody were found in the pretreatment sera of the patients. CONCLUSIONS: High doses of recombinant adenoviruses could be safely administered to cancer patients. High levels of neutralizing antibody present in patients' sera prior to treatment may have impaired the ability of these viruses to immunize patients against melanoma antigens.     

High-k Al/sub 2/O/sub 3/ gate dielectrics prepared by oxidation of aluminum film in nitric acid followed by high-temperature annealing

A simple, cost-effective, and room temperature process was proposed to prepare high-k gate dielectrics. An aluminum oxide (Al/sub 2/O/sub 3/) gate dielectric was prepared by oxidation of ultrathin Al film in nitric acid (HNO/sub 3/) at room temperature then followed by high-temperature annealing in O/sub 2/ or N/sub 2/. The substrate injection current behavior and interface trap-induced capacitance were introduced to investigate the interfacial property between the gate dielectric and Si substrate. Al/sub 2/O/sub 3/ gate dielectric MOS capacitors with and without initial SiO/sub 2/ layers were characterized. It was shown that the Al/sub 2/O/sub 3/ gate dielectrics with initial oxide exhibit better electrical properties than those without. The 650/spl deg/C N/sub 2/-POA Al/sub 2/O/sub 3/-SiO/sub 2/ sample with an equivalent oxide thickness of 18 /spl Aring/ exhibits three orders of magnitude reduction in gate leakage current in comparison with the conventional thermal SiO/sub 2/ sample.     

Compilers for improved Java performance

Because they are interpreted, Java executables run slower than their compiled counterparts. The native executable translation (NET) compiler's objective is to optimize the translation of Java byte-code to native machine code so that it runs nearly as fast as native code generated directly from a source. The article presents some preliminary results for several large application programs and standard benchmarks. It compares the NET-compiled code performance with Sun's Java VM, Microsoft's Java just-in-time compiler, and equivalent C and C++ programs directly compiled. The results show that the optimizing NET compiler is capable of achieving better performance than the two other byte-code execution methods, in some cases achieving speeds comparable to directly compiled native code     

Enhanced power performance of enhancement-mode Al0.5Ga0.5As/In0.15Ga0.85As pHEMTs using alow-k BCB passivation

Surface passivation technology plays an important role, especially in E-mode pHEMTs applications, and a new passivation technology has been proposed in this study. This novel benzocyclobutene (BCB) passivation layer takes advantage of the low dielectric permittivity (2.7) and a low loss tangent (0.0008). In this letter, we not only suppress the gate-to-drain leakage current but also improve the device power performance under a high input power swing by using a BCB passivation layer. The passivated 1.0 μm-long gate pHEMTs exhibit a better off-state performance than the unpassivated ones. The maximum output power under a 2.4-GHz operation is 118 mW/mm, with a linear power gain of 11.1 dB and a power-added efficiency is 60%     

K-band monolithic InGaP-InGaAs DCFET amplifier using BCB coplanar waveguide technology

A K-band (20 GHz) monolithic amplifier was developed and fabricated by adopting a low-/spl kappa/ benzocyclobutene (BCB) coplanar waveguide (CPW) line and InGaP-InGaAs doped-channel HFETs (DCFETs). This monolithic microwave integrated circuit (MMIC) utilizes a high impedance BCB CPW microstrip line (Z/sub 0/=70 /spl Omega/) for the biasing circuits, and a Z/sub 0/=50 /spl Omega/ line for the RF signal transmission. The low dielectric constant characteristic of the BCB interlayer is beneficial for a common-ground bridge process, which reduces the parasitics. The calculated loss tan/spl delta/ is 0.036 for the BCB at 20 GHz. The one-stage MMIC amplifier achieves an S/sub 21/ of 5 dB at 20 GHz, which is the first demonstration of the K-band InGaP-InGaAs DCFET monolithic circuit.     

Boundary element analysis for viscoelastic solids containing interfaces/holes/cracks/inclusions

With the aid of the elastic–viscoelastic correspondence principle, the boundary element developed for the linear anisotropic elastic solids can be applied directly to the linear anisotropic viscoelastic solids in the Laplace domain. Green's functions for the problems of two-dimensional linear anisotropic elastic solids containing holes, cracks, inclusions, or interfaces have been obtained analytically using Stroh's complex variable formalism. Through the use of these Green's functions and the correspondence principle, special boundary elements in the Laplace domain for viscoelastic solids containing holes, cracks, inclusions, or interfaces are developed in this paper. Subregion technique is employed when multiple holes, cracks, inclusions, and interfaces exist simultaneously. After obtaining the physical responses in Laplace domain, their associated values in time domain are calculated by the numerical inversion of Laplace transform. The main feature of this proposed boundary element is that no meshes are needed along the boundary of holes, cracks, inclusions and interfaces whose boundary conditions are satisfied exactly. To show this special feature by comparison with the other numerical methods, several examples are solved for the linear isotropic viscoelastic materials under plane strain condition. The results show that the present BEM is really more efficient and accurate for the problems of viscoelastic solids containing interfaces, holes, cracks, and/or inclusions.     

Biocompatible transferrin-conjugated sodium hexametaphosphate-stabilized gold nanoparticles: synthesis, characterization, cytotoxicity and cellular uptake

The feasibility of using gold nanoparticles (AuNPs) for biomedical applications has led to considerable interest in the development of novel synthetic protocols and surface modification strategies for AuNPs to produce biocompatible molecular probes. This investigation is, to our knowledge, the first to elucidate the synthesis and characterization of sodium hexametaphosphate (HMP)-stabilized gold nanoparticles (Au-HMP) in an aqueous medium. The role of HMP, a food additive, as a polymeric stabilizing and protecting agent for AuNPs is elucidated. The surface modification of Au-HMP nanoparticles was carried out using polyethylene glycol and transferrin to produce molecular probes for possible clinical applications. In vitro cell viability studies performed using as-synthesized Au-HMP nanoparticles and their surface-modified counterparts reveal the biocompatibility of the nanoparticles. The transferrin-conjugated nanoparticles have significantly higher cellular uptake in J5 cells (liver cancer cells) than control cells (oral mucosa fibroblast cells), as determined by inductively coupled plasma mass spectrometry. This study demonstrates the possibility of using an inexpensive and non-toxic food additive, HMP, as a stabilizer in the large-scale generation of biocompatible and monodispersed AuNPs, which may have future diagnostic and therapeutic applications.     

Benchmark characterization

An abstract system of benchmark characteristics that makes it possible, in the beginning of the design stage, to design with benchmark performance in mind is presented. The benchmark characteristics for a set of commonly used benchmarks are then shown. The benchmark set used includes some benchmarks from the Systems Performance Evaluation Cooperative. The SPEC programs are industry-standard applications that use specific inputs. Processor, memory-system, and operating-system characteristics are addressed